Louisville, ky a case is reported in which a patient with longstanding rheumatoid arthritis ra developed bullous pemphigoid bp. Autoimmune disease, bullous pemphigoid, corticosteroids. Case report clinical diagnosis and a shortterm treatment of. Bullous pemphigoid is an autoimmune blistering disorder that typically presents in elderly patients as pruritic tense subepidermal blisters on the lower trunk, axilla, and groin. A case report of bullous pemphigoid associated with a melanoma. Cases of druginduced bullous pemphigoid bp have been reported in association with spironolactone, furosemide, chloroquine. Bullous pemphigoid associated with acquired hemophilia a. A case of oropharyngeal bullous pemphigoid presenting with. He did not present with any abdominal pain, blood pressure was 179 mm hg and urinary protein. Bullous pemphigoid bp is a autoimmune blistering disease encountered in india. Localized bullous pemphigoid is a rare variant of bullous pemphigoid, and its exact etiopathogenesis is yet to be elucidated. Aug 29, 2018 bullous pemphigoid bp is an autoimmune blistering skin disorder characterized by diffuse, erythematous and pruritic skin lesions that often begin as papular andor urticarial, before transforming into deeper and tense vesico.
We report a case of bullous pemphigoid presenting with haemoptysis, initially presenting to the ear, nose and throat department for investigation. Case report open access erythrodermic psoriasis with bullous pemphigoid. Successful management of bullous pemphigoid with dimethyl. The condition started some eight weeks previously when.
A 9yearold boy presented with a 1day history of a palpable purpuric rash on his lower limbs 3 days after a viral illness. Bullous pemphigoid bp is a blistering skin disorder infrequent in infancy and rarely reported in medical. Childhood bullous pemphigoid a case report dear editor, bullouspemphigoid bpusuallyaffectsthe elderly,but bpin infancy has also been reported. Bullous pemphigoid bp is an autoimmune subepidermal dermatosis that generally affects people older than 70 years, with no ethnic, racial or sexual predilection. We report the case of a 71yearold woman with pemphigoid nodularis.
Bullous pemphigoid is well known for its cutaneous features. To the best of our knowledge we present the first case report of atenololinduced mucous membrane pemphigoid. Bp, including nodular pemphigoid, pemphigoid vege tans, lichen planus pemphigoides and. Infusions are administered monthly over 15days in the hospital setting and associated with mild to severe infusionrelated systemic effects, in part.
Bullous pemphigoid associated with dipeptidyl peptidase. Juvenile bullous pemphigoid a case report article pdf available in serbian journal of dermatology and venereology 51 june 20 with 972 reads how we measure reads. For some patients, with long mean duration of symptoms, the correct diagnosis of pn is delayed because the. In conclusion, we report a case of bp associated with chronic renal allograft rejection in a young man with renal allograft, the probable triggering factor for the development of the bullous disease. A 15monthold boy presented with recurrent blisters on his face, trunk, and extremities 1 month later after receiving measles. We present a case of a 74yearold caucasian male with a 3month history of skin lesions that appeared 9 months after he underwent a knee arthroplasty. We report a case of bp following administration of certain medication.
Interstitial pneumonia associated with bullous pemphigoid. Pdf on jan 26, 2016, chunbing chen and others published childhood bullous pemphigoida case report find, read and cite all the. Bullous pemphigoid bp is a rare autoimmune skin disease with the predilection on the elderly. It is a subepidermal bullous disorder commonly seen in the older generations. Bullous pemphigoid bp is an autoimmune subepidermal blistering disorder that results in large tense bullae, which is induced. It presents as bullous pemphigoid like bullae, and at times can even induce the formation of true bullous pemphigoid lesions. Bp commonly affects older patients and females are slightly more affected than males. Dyshidrosiform bullous pemphigoid is a rare variant of bullous. The aim of this case report is to present a classic case of this condition. Mucous membrane pemphigoid in a patient with hypertension.
Bullous pemphigoid triggered by swine flu vaccination. Lung disorders associated with bullous pemphigoid are extremely rare, and, to our knowledge, this is the first report of an immunologically confirmed case of interstitial pneumonia. Mucous membrane pemphigoid has been known by many different names within the medical literature including benign mucous membrane pemphigoid, cicatricial scarring pemphigoid, and ocular cicatricial pemphigoid. It presents clinically with diffuse eczematous, pruritic, urticarialike lesions, with the later appearance of tense bullae or blistering lesions typically filled with clear fluid. The features of the present case report are similar to the ones reported in the literature, highlighting the elderly patient group, presenting initial papulonodular pruritic lesions and secondary vesicular bullous lesions or urticarial plaques. Three case reports of post immunization and post viral. We report two cases of children with bullous pemphigoid. Recent studies report the presence of the bullous pemphigoid antigen, bp180, in melanoma cells, yet not normal melanocytes, suggesting an underlying. Dec 05, 2018 pemphigoid nodularis pn is a rare clinical variant of bullous pemphigoid characterized by the presence of nodular prurigolike lesions and pemphigoid blisters. Case report open access erythrodermic psoriasis with bullous. A case report erin streu1, marni c wiseman2 and james b johnston3,4 abstract intravenous immunoglobulin is a recognized treatment in recalcitrant autoimmune bullous diseases. Clinical features, outcomes, and risk of bp for new dpp4i linagliptin, saxagliptin, and alopgliptin are not well established. Previous reports have suggested that vaccination can be a trigger for pemphigoid and this report describes the first known case of swine flu triggered bullous pemphigoid. Bullous pemphigoid bp is an autoimmune subepidermal blistering disease that predominantly affect elderly more than 60 years of age.
Bullous pemphigoid bp is the most common autoimmune bullous disease affecting the skin and mucosal membranes, with antibodies directed against the 180kda bp antigen bp180 and the 230kda bp antigen bp230 located in the basement membrane zone. Successful management of bullous pemphigoid with dimethyl fumarate therapy. Bullous eruption was easily controlled by systemic corticosteroids and did not recur after graft nephrectomy during a clinical followup of 8 months. Bullous pemphigoid bp is an acquired autoimmune blistering disease characterized by the formation of autoantibodies against hemidesmosomal antigens bp180 and bp230. Nov 15, 2016 bullous pemphigoid bp is an autoimmune skin disease with incidence varying between 0. Development of bullous pemphigoid during nivolumab therapy. Bullous pemphigoid is an autoimmune blistering condition that usually occurs in elderly individuals. There are a number of variants of bullous pemphigoid. Psychiatric and neurological disorders are associated with. Bp with typical histology and direct immunofluorescence studies. The skin biopsy findings obtained from the patient were consistent with the diagnosis of bullous pemphigoid bp. Pemphigoid nodularis pn is a rare clinical variant of bullous pemphigoid characterized by the presence of nodular prurigolike lesions and pemphigoid blisters.
Case report an 82yearold retired engineer was referred complaining of a sore mouth, throat and under surface of tongue. One week later, he developed arthralgia in his lower limbs, facial oedema and progression of the rash to his buttocks and lower arms. Pemphigoid nodularis rare presentation of bullous pemphigoid. Case report open access mucous membrane pemphigoid in a. This atypical onset of pn partially explains the diagnosis delay, especially in the absence of obvious clinical signs of bp. Although igg autoantibodies predominate within the plasma and skin of bp patients, some features of the disease cannot be explained solely by iggmediated mechanisms. Clinical diagnosis and a shortterm treatment of bullous pemphigoid in an adult yemeni female. He was also suffering from blisters and ulcers on the limbs and chest. The purpose of this report is to include in the literature a case of bullous pemphigoid which presented initially with oral signs and symptoms. Few studies shows autoimmune bullous diseases associated with human immunodeficiency virus hiv. Here, we report a case of bullous pemphigoid bp, which began shortly after initiating treatment with the pd1 inhibitor nivolumab. Bullous pemphigoid is the most common of the blistering disorders.
A 42yearold thai man presented to our faculty after developing. The immunopathogenesis of the disease is attributed to circulating and tissuebound autoantibodies directed against bullous pemphigoid antigen 230 bullous pemphigoid antigen 1 or bullous pemphigoid antigen 180 bullous pemphigoid antigen 2 or both. Bullous pemphigoid in a chronic renal allograft rejection. We report a case of bullous pemphigoid presenting with haemoptysis, initially presenting to the ear, nose and roat department for investigation. Case report open access mucous membrane pemphigoid in a patient with hypertension treated with atenolol. A consensus group of researchers in 20021 determined that mucous membrane pemphigoid was the. Bullous pemphigoid is an acute or chronic autoimmune skin disease causing the formation of blisters bullae in the epidermal and dermal junction. It is caused by circulating and tissuebound autoantibodies directed against bullous pemphigoid antigen 1 or bullous pemphigoid antigen 2 or both. The diagnosis is confirmed by direct immunofluorescence dif indirect immunofluorescence iif and immunoserology tests. These medications can induce a variety of cutaneous eruptions, the full spectrum of which is not yet completely characterized. Pdf abstract bullous pemphigoid is an autoimmune rare disorder occurring both in male and female with more number among females.
Several variants of bullous pemphigoid have been reported including pemphigoid nodularis. We describe the case of a 75yearold woman who presented with new onset of erythematous and bullous lesions 5 days after receiving. We hereby report a case of metronidazole induced bullous pemphigoid bp in a 52yearold male patient suffering from liver abscess following 4 days of drug administration. Pdf childhood bullous pemphigoida case report researchgate.
There have been reports of various adverse effects associated with the use of atenolol including bullous pemphigoid. Localized bullous pemphigoid on the site of knee arthroplasty. Localized bullous pemphigoid lbp is a specific form of bullous pemphigoid. Bullous pemphigoid bp has been associated with dipeptidyl peptidase. The first one was a case of a 4monthold female infant, whereas the second is of a 3monthold male infant. A possible case of bullous pemphigoid bp that developed during treatment with ustekinumab is reported. Patients with pemphigoid nodularis have clinical features of prurigo nodularis in combination with clinical or immunologic characteristics of bullous pemphigoid. It is most commonly found in the elderly and is diagnosed based on clinical, histologic, and immunologic criteria. The exact pathophysiology underlying the disorder remains incompletely understood. Case report a case of oropharyngeal bullous pemphigoid.
It is the variant most likely to occur in the oral cavity and eyes. Atenolol is commonly used by patients with hypertension, angina pectoris, or myocardial infarction. The ageadjusted incidence of bp has been reported to be on the rise 1,2,3. Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately known as bullae, at the space between the skin layers epidermis and dermis. A case report of bullous pemphigoid induced by dipeptidyl. Lowdose subcutaneous immunoglobulin is an effective.
She also complained of a spreading, pruritic, bullous rash, which rst began three weeks previously. Case report, infant, bullous pemphigoid, drug therapy, vaccination background bullous pemphigoid bp is an autoimmune blistering skin disorder associated with presence of tissuebound and circulating igg autoantibodies directed against hemidesmosomal proteins, called bp antigen 180 and bp antigen 230 1. Bullous pemphigoid bp is a common chronic autoimmune subepidermal blistering disease that commonly affects the elderly. Autoimmune bullous diseases are characterized by bullous lesions to the skin and mucous membranes of the oral cavity, nose, eyes, larynx, pharynx, esophagus, and genitals.
Nov 22, 2008 mucous membrane pemphigoid mmp is a rare group of chronic autoimmune disorders characterized by blister producing lesions. Localized bp is one of the clinical variants of pemphigoid, which comprises three basic entities based on the affected site and disease consequence. Ustekinumab is a human monoclonal antibody found in pathologies such as psoriasis, which works by inhibiting the activity of interleukin12 and interleukin23. Dyshidrosiform bullous pemphigoid is a rare variant of bullous pemphigoid, and it usually presents as itchy, potentially hemorrhagic, or purpuric blisters on the palms andor soles of elderly individuals. Case report open access three case reports of post immunization and post viral bullous pemphigoid.
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